Molecular Imaging Versus Adrenal Vein Sampling for the Detection of Surgically Curable Primary Aldosteronism : A Prospective Within-Patient Trial.

• Tác giả: Elizabeth Adeyeye, Franklin Aigbirhio, Giulia Argentesi, Waiel A Bashari, Daniela Benu, Daniel M Berney, Nicholas Bird, Morris J Brown, Claudia P Cabrera, Heok Cheow, Aldons C N Chua, J Kennedy Cruickshank, Anne Dawnay, William M Drake, Kiera Drew, Roger Foo, Daniel Gillett, Emily Goodchild, Mark Gurnell, Nicholas Hilliard, Matthew Hird, Jessica Kearney, Brendan Koo, Vasilis Kosmoliaptsis, Kate Laycock, Yun-Ni Lee, James MacFarlane, Alison Marker, Matthew Matson, Alex McConnachie, Alasdair McIntosh, Charles A Mein, Samuel M O'Toole, Laila Parvanta, Anju Sahdev, Jackie Salsbury, Emanuel Savage, Russell Senanayake, Graham Smith, Wilson Tan, Victoria Warnes, Eva Wozniak, Xilin Wu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 614.45 Patient isolation
• Thông tin xuất bản: United States : Annals of internal medicine , 2025
• Bộ sưu tập: NCBI
• ID: 692847

Tóm tắt

 BACKGROUND: Primary aldosteronism (PA) causes hypertension and is potentially surgically curable when it is caused by a unilateral aldosterone-producing adrenal adenoma (APA). Adrenal vein sampling (AVS) is required to guide surgery, but it is invasive, is technically difficult, and has limited availability. OBJECTIVE: To determine whether the accuracy of post-dexamethasone [ DESIGN: Prospective within-patient comparison of diagnostic interventions. (ClinicalTrials.gov: NCT02945904). SETTING: Three referral centers. PARTICIPANTS: 174 patients with PA desiring surgery if a unilateral source of PA was diagnosed. INTERVENTION: [ MEASUREMENTS: International consensus criteria for biochemical and clinical success at 6 and 24 months after surgery
  κ statistic and Bland-Altman analyses comparing predictions of surgical outcomes by [ RESULTS: Eighty-nine of 169 (52.7%), 78 of 169 (46.2%), and 43 of 169 (25.4%) patients were predicted to have unilateral PA by [ LIMITATION: The accuracy of [ CONCLUSION: Molecular imaging is an accurate, noninvasive alternative to AVS. PRIMARY FUNDING SOURCE: National Institute for Health and Care Research.