Resting-state EEG network variability predicts individual working memory behavior.

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Tác giả: Chunli Chen, Fali Li, Peng Xu, Shiyun Xu, Dezhong Yao, Chanlin Yi, Liang Yu, Yangsong Zhang, Jixuan Zhou

Ngôn ngữ: eng

Ký hiệu phân loại: 331.1204 Labor force and market

Thông tin xuất bản: United States : NeuroImage , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 692962

Even during periods of rest, the brain exhibits spontaneous activity that dynamically fluctuates across spatially distributed regions in a globally coordinated manner, which has significant cognitive implications. However, the relationship between the temporal variability of resting-state networks and working memory (WM) remains largely unexplored. This study aims to address this gap by employing an EEG-based protocol combined with fuzzy entropy. First, we identified both flexible and robust patterns of dynamic resting-state networks. Subsequently, we observed a significant positive correlation between WM performance and network variability, particularly in connections associated with the frontal, right central, and right parietal lobes. Moreover, we found that the temporal variability of network properties was positively and significantly associated with WM performance. Additionally, distinct patterns of network variability were delineated, contributing to inter-individual differences in WM abilities, with these distinctions becoming more pronounced as task demands increased. Finally, using a multivariable predictive model based on these variability metrics, we effectively predicted individual WM performances. Notably, analogous analyses conducted in the source space validated the reproducibility of the temporal variability of resting-state networks in predicting individual WM behavior at higher spatial resolution, providing more precise anatomical localization of key brain regions. These results suggest that the temporal variability of resting-state networks reflects intrinsic dynamic changes in brain organization supporting WM and can serve as an objective predictor for individual WM behaviors.
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