An atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis.

• Tác giả: Maida Avdic, Alexander Bartelt, Jürgen Bernhagen, Priscila Bourilhon, Markus Brandhofer, Richard Bucala, Elina Bugar, Yvonne Döring, Simon Ebert, Omar El Bounkari, Meinrad Gawaz, Simona Gerra, Ozgun Gokce, Mark Haid, Tobias Harm, Adrian Hoffmann, Yvonne Jansen, Hao Ji, Aphrodite Kapurniotu, Wolfgang E Kempf, Christos Kontos, Naomi Kramer, Lars Maegdefessel, Remco T A Megens, Denise Messerer, Jelena Milic, Dominik Rath, Fabien Riols, Nadja Sachs, Christian Schulz, Dzmitry Sinitski, Jonas Wagner, Christian Weber, Nienke Willemsen, Bishan Yang, Chunfang Zan, Marlies Zarwel
• Ngôn ngữ: eng
• Ký hiệu phân loại: 657.046 Advanced level
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 693031

Tóm tắt

Atherosclerosis is the underlying cause of myocardial infarction and ischemic stroke. It is a lipid-triggered and cytokine/chemokine-driven arterial inflammatory condition. We identify D-dopachrome tautomerase/macrophage migration-inhibitory factor-2 (MIF-2), a paralog of the cytokine MIF, as an atypical chemokine promoting both atherosclerosis and hepatic lipid accumulation. In hyperlipidemic Apoe