Canine genome-wide association study identifies

• Tác giả: Rebecca Bounds, Justine Chan, Marie Dittmann, Georgina K C Dowsett, I Sadaf Farooqi, Philippe Froguel, Alexander J German, Caroline M Gorvin, Aqfan Jamaluddin, Katherine A Kentistou, Sambhavi S Kumar, Jane Ladlow, Gabriella Lakatos, Brian Y H Lam, Marcella Ma, Alyce McClellan, Anna Morros-Nuevo, Alexander Mörseburg, Ken K Ong, John R B Perry, Eleanor Raffan, Kara Rainbow, Sadia Saeed, David Sargan, Ellen Schofield, Natasha T Sumanasekera, John A Tadross, Jodie F Wainwright, Natalie J Wallis, David Withers, Giles S H Yeo, Rey M Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 623.748 Air-cushion vehicles
• Thông tin xuất bản: United States : Science (New York, N.Y.) , 2025
• Bộ sưu tập: NCBI
• ID: 693053

Tóm tắt

Obesity is a heritable disease, but its genetic basis is incompletely understood. Canine population history facilitates trait mapping. We performed a canine genome-wide association study for body condition score, a measure of obesity, in 241 Labrador retrievers. Using a cross-species approach, we showed canine obesity genes are also associated with rare and common forms of obesity in humans. The lead canine association was within the gene DENN domain containing 1B (