An obesogenic FTO allele causes accelerated development, growth and insulin resistance in human skeletal muscle cells.

• Tác giả: Yu Chen, Lu Guang, Shuqing Liu, Lanfang Luo, Shilin Ma, Ng Shyh-Chang, Dan Song, Jiali Su, Peng Wang, Yuefan Wang, Ziyue Yao
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 693070

Tóm tắt

Human GWAS have shown that obesogenic FTO polymorphisms correlate with lean mass, but the mechanisms have remained unclear. It is counterintuitive because lean mass is inversely correlated with obesity and metabolic diseases. Here, we use CRISPR to knock-in FTO