The LRP1-SHP2 pathway regulates TRPV1 sensitivity in the peripheral nervous system: Insights from amyloid beta 1-42 modulation.

• Tác giả: Temugin Berta, Gehoon Chung, Eun Jin Go, Inbo Han, Sung-Min Hwang, YunJae Jung, Yong Ho Kim, Sang Hoon Lee, Sun-Ho Lee, Jing-Ying Pan, Chul-Kyu Park, Jaeik Park, Mahbubur Rahman, Jueun Roh
• Ngôn ngữ: eng
• Thông tin xuất bản: Egypt : Journal of advanced research , 2025
• Bộ sưu tập: NCBI
• ID: 693246

Tóm tắt

INTRODUCTION: Mature adults often exhibit higher pain thresholds than younger individuals. However, this phenomenon is poorly understood, especially with regards to peripheral nervous system signaling. OBJECTIVES: We investigated the involvement of amyloid beta (Aβ) in regulating heat pain sensitivity within the dorsal root ganglion (DRG) during adult maturation. METHODS: We employed various in vivo and in vitro techniques to investigate the modulatory effect of Aβ RESULTS: Mature adult mice had higher thermal pain thresholds and elevated levels of Aβ CONCLUSION: The findings suggest a crucial role of Aβ in modulating heat pain sensitivity during maturation through TRPV1 inhibition. The study offers new insights into the regulation of pain sensitivity during the maturation process by revealing a novel intrinsic mechanism involving Aβ