Microfluidic development of liposome nanoparticles encapsulated with yam polysaccharide.

• Tác giả: Lian Cen, Yuehan Cui, Ruilai Liu, Meng Song, Zhenhao Xi, Ling Zhao
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of pharmaceutical sciences , 2025
• Bộ sưu tập: NCBI
• ID: 693282

Tóm tắt

A novel liposome nanoparticle loaded with yam polysaccharide was developed in this study via a tailor-made microfluidic device and further optimized through the Box-Behnken Design method of surface analysis to exploit combinational immunomodulatory effects of liposomes and yam polysaccharide. A chip of 100 μm in height and 200 μm in width with a mixing channel with embedded baffles to enhance fluid mixing was first designed and fabricated. Liposome nanoparticles were obtained by manipulating the operating parameters of the microfluidic chip. The formulation of yam polysaccharide loaded liposomes (YPL