Spectroscopic and molecular docking studies on binding interactions of camptothecin drugs with bovine serum albumin.

• Tác giả: Jiao Chen, Bingmiao Gao, Junfeng Li, Xuanda Li, Yun Song, Yuhe Wang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 615.2—615.3 Inorganic drugs
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 693313

Tóm tắt

This study investigates the binding interactions between bovine serum albumin (BSA) and camptothecin (CPT) drugs (camptothecin, 10-hydroxycamptothecin, topotecan, and irinotecan) using UV-Vis spectroscopy, fluorescence spectroscopy, three-dimensional fluorescence spectroscopy, and molecular docking techniques. The fluorescence quenching of BSA by CPT drugs follows a static mechanism, with binding constants (K