Genomic relatedness of colonizing and invasive disease Klebsiella pneumoniae isolates in South African infants.

• Tác giả: Lubomira Andrew, Ziyaad Dangor, Nicholas J Dean, Robert G K Donald, Alane Izu, Stephanie Jones, Shama Khan, Gaurav Kwatra, Fikile C Mabena, Shabir A Madhi, Niree Naidoo, Firdose L Nakwa, Courtney P Olwagen, Urvi Rajyaguru, Yogandree Ramsamy, Mohamed Said, Raphael Simon, Renate Strehlau, Lara Van der Merwe, Anika M van Niekerk, Sithembiso C Velaphi, Jeannette Wadula
• Ngôn ngữ: eng
• Ký hiệu phân loại: 618.92000832 Pediatrics and geriatrics
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 693323

Tóm tắt

 Klebsiella pneumoniae (KPn) colonizes multiple anatomical sites and is a leading cause of invasive disease and death in African children
  however, there is no comparative genomic analysis between colonizing and invasive strains. This study investigated the genomic relatedness of KPn colonizing and invasive isolates in South African infants
  and evaluated the relative invasiveness of KPn isolates based on sequence types (ST), capsular (KL), and lipopolysaccharide (O) loci by calculating case-carrier ratios (CCRs). There was less genomic diversity amongst invasive (22 ST, 17 K-loci) than colonizing isolates (31 ST, 29 K-loci), with invasive isolates being 8.59-fold and 3.49-fold more likely to harbour genes encoding for multi-drug resistance and yersiniabactin production compared with colonizing isolates. The CCRs for KL102 and O1/O2v2 were >
  1, and <
  1 for KL8, ST1414, and O1O2v1. Identifying high-risk strains, including KL102 and O1O2v2, that may have a higher potential to cause invasive disease, could enhance risk assessment and management strategies in vulnerable populations.