Land is an essential component of the natural eco-system, the source of human existence, and has a crucial influence on the future health development and stability of human society. Analyzing the status of land eco-safety in the Pearl River Delta area can provide a scientific basis and decision-making support for the sustainable use of land resources in the Pearl River Delta region. At the same time, it can reveal the complex factors affecting the eco-safety of land resources in the region and their interaction mechanisms. Based on the 2012-2021 data of the Pearl River Delta area municipalities, This study chooses the DPSIR theory to construct the land resource eco-safety evaluation system, which contains 5 criterion layers and 21 indicator layers. The evaluation system not only integrates the systematic and hierarchical advantages of the DPSIR theoretical but also makes full use of the flexibility of the fuzzy comprehensive evaluation method in dealing with uncertainty, effectively improving the accuracy and reliability of the evaluation. The spatial visualization tool Quantum GIS(QGIS) and objective evaluation index method entropy weight method topsis(EWM-TOPSIS) were applied to assess the land ecological situation in the Pearl River Delta area from 2012 to 2021. The correlation coefficients between the land eco-safety condition in the Pearl River Delta area and the influencing factors were derived using gray correlation analysis (GCA). The results show that (1) there is a differentiation in the land resource eco-safety status among the cities in the Pearl River Delta area, with Jiangmen (0.495) in the best condition and Dongguan (0.425) in the worst condition compared to the other eight cities. (2) During the study period, the Pearl River Delta's land resource eco-safety composite index area increased by 187.23%. The land status shows the stage characteristics of small climb, smooth improvement, and flat. (3) The deficiency of land ecological management system and policy was revealed, and the optimization and perfection of management system was put forward as the key factor to improve urban ecological security.