BACKGROUND: Wound healing is one of the most interesting topics in orthopaedic surgery, and there are many studies on the factors and mechanisms affecting this process. OBJECTIVES: To evaluated the macroscopic and histopathological results of drone larvae homogenate (DLH) on wound healing in a full-thickness wound model. METHODS: Thirty male wistar rats (6-8 weeks, 250 ± 50 g) were used. A uniform circular full-thickness wound of approximately 18.44 ± 1.45 (control), 19.02 ± 1.24 (silverdin), 19.37 ± 1.28 (DLH) mm RESULTS: There was no statistically significant difference in lymphocyte, fibroblast, scar thickness, polymorphonuclear leukocyte (PMNL), minivascular density (CD34) and transforming growth factor-β1 (TGF-β1) among the control, silverdin and DLH groups (p = 0.771, 0.434, 0.07, 0.396). The scar density of the DLH group was found to be higher than the control and silverdin groups (p = 0.003). The average wound diameter of the control group (6.87 ± 0.93 mm CONCLUSIONS: DLH has a positive effect on wound healing, especially by ensuring early wound contraction and wound scar formation.