Effect of 12-week dietary nitrate supplementation on carotid arterial stiffness in postmenopausal females.

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Tác giả: Thiago Silveira Alvares, Vivian Dos Santos Pinheiro, Rogerio Nogueira Soares, David N Proctor

Ngôn ngữ: eng

Ký hiệu phân loại: 324.27327 Political parties

Thông tin xuất bản: United States : American journal of physiology. Heart and circulatory physiology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 693735

Menopause is associated with reduced nitric oxide (NO) bioavailability, a key contributor to increased arterial stiffness and, consequently, greater risk of cardiovascular disease (CVD)-related mortality in postmenopausal females. Even though dietary nitrate has been shown to increase NO bioavailability in postmenopausal females acutely, previous studies showed no impact of dietary nitrate supplementation on arterial stiffness in postmenopausal females. Their findings were likely limited by the acute and/or short-term design. Thus, this study aimed to determine whether 12 weeks of dietary nitrate supplementation via beetroot extract improves carotid artery stiffness in postmenopausal females. A randomized, double-blind, placebo-controlled, and parallel-design trial was conducted with 20 postmenopausal females (60-85 years). Participants received nitrate-rich (NR-BEETx, 8.8 mmol/day) or nitrate-depleted (ND-BEETx) beetroot extract. Carotid stiffness parameters-pulse wave velocity (PWV
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