Resistance to quorum sensing inhibition spreads more slowly during host infection than antibiotic resistance.

• Tác giả: Tom Defoirdt
• Ngôn ngữ: eng
• Ký hiệu phân loại: 636.7538 Dogs
• Thông tin xuất bản: United States : Gut microbes , 2025
• Bộ sưu tập: NCBI
• ID: 693801

Tóm tắt

Antibiotic resistance is a rising problem and new and sustainable strategies to combat bacterial (intestinal) infections are therefore urgently needed. One promising strategy under intense investigation is the inhibition of quorum sensing, bacterial cell-to-cell communication with small molecules. A key question with respect to the application of quorum sensing inhibition is whether it will impose selective pressure for the spread of resistance. It was recently shown that resistance to quorum sensing inhibition will spread more slowly during infection of a host than resistance to traditional antibiotics.