Results of rapid plasma direct oral anticoagulant levels greatly expand stroke thrombolysis eligibility: evidence from real-world implementation.

• Tác giả: Marija Borosak, Edward Callaly, Philip M C Choi, Helen Dewey, Ben Holland, Jason Tjahyadi, Vicky Yin
• Ngôn ngữ: eng
• Ký hiệu phân loại: 347.064 Kinds of evidence
• Thông tin xuất bản: Australia : Internal medicine journal , 2025
• Bộ sưu tập: NCBI
• ID: 693887

Tóm tắt

 Direct oral anticoagulants (DOACs) are used for stroke prevention in atrial fibrillation, but their presence can limit thrombolysis eligibility in acute stroke. This retrospective study examined whether rapid plasma DOAC testing expanded eligibility for thrombolysis. Among ischaemic stroke patients taking DOACs who were otherwise eligible for thrombolysis, 40% had low DOAC levels (<
 50 ng/mL). This led to the use of potentially life- and disability-saving thrombolysis in patients who would otherwise have been ineligible.