Structure-Based Optimization of Moracin M as Potent and Selective PDE4 Inhibitors with Antipsoriasis Effects.

• Tác giả: Yu Chen, Yi-You Huang, Xingfu Liu, Hai-Bin Luo, Sen Wang, Xue Wang, Deyan Wu, Qi Wu, Shenghong Xie, Chao Xu, Guofeng Yang, Feng Zhang, Furong Zhang, Tiansheng Zheng, Qian Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 966.8303 Togo and Benin
• Thông tin xuất bản: United States : Journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 694071

Tóm tắt

Psoriasis is a complex chronic inflammatory disease that severely affects the quality of life of patients. However, current medications could only control the symptoms but not cure psoriasis with unmet medical needs. Herein, structure-based optimizations of natural product moracin M (IC