Amikacin dosing in neonates: evaluation of target attainment using a simplified and complex pharmacokinetic model-derived dosing regimen in clinical practice.

• Tác giả: Karel Allegaert, Yuma A Bijleveld, Timo R de Haan, Linda G W Franken, Caspar J Hodiamont, Ron A A Mathôt, Anne Smits, Marlotte A A van der Veer, Anton H van Kaam
• Ngôn ngữ: eng
• Ký hiệu phân loại: 729.6 Decoration in veneer and incrustation
• Thông tin xuất bản: United States : Antimicrobial agents and chemotherapy , 2025
• Bộ sưu tập: NCBI
• ID: 694156

Tóm tắt

Amikacin is frequently used for the treatment of neonatal sepsis. The Dutch Pediatric Formulary recommends a complex pharmacokinetic (PK) model-derived dosing regimen, which consists of dosing categories based on postnatal age and weight that results in adequate PK/pharmacodynamic (PK/PD) target attainment. However, a simplified dosing regimen may be easier to apply in clinical practice. We evaluated PK/PD target attainment of amikacin in neonates using this simplified or complex dosing regimen. This retrospective cohort study included neonates with routinely measured amikacin concentrations at the neonatal intensive care units of the Amsterdam University Medical Center (simplified dosing regimen) or University Hospitals Leuven (complex dosing regimen). Peak (C