OBJECTIVE: Patients with uncontrolled epilepsy are at high risk for sudden unexpected death in epilepsy (SUDEP), which likely results from a pathological, seizure-induced disruption of vital physiological systems. The objective of this study was to characterize seizure-induced physiological dysfunction leading to death in SS METHODS: Male and female SS RESULTS: Time-restricted audiogenic seizures in SS SIGNIFICANCE: Understanding the causes of SUDEP in patients with epilepsy is limited due to unpredictable and heterogeneous circumstances and incomplete physiological data. This study provides insights into seizure-induced and delayed physiological decompensation leading to SUDEP-like events, demonstrating a need for additional prospective, integrated physiological measures for a more complete picture of SUDEP.