Structural defects and biological inertness significantly impair the integration of titanium alloy implants and bone tissues. In spinal internal fixation, the issue of pedicle screw loosening or fracture caused by poor integration urgently needs solving. In this study, we utilized 3D printing technology to custom fabricate a structurally optimized porous pedicle screw with the aim of enhancing bone regeneration and integration at the defect site, thereby enhancing the biological fixation of the implant