The complement system's distinguishing feature is its cell-specific surface ligands. However, the limited scalability and complexity of incorporating surface-customizable ligands into membrane-bound cell-like microassemblages have hindered their widespread adoption in synthetic biology and bioengineering. Here, we present a method for the batch construction of polysaccharide-based microcapsules (polysaccharidosomes, P-somes) with intrinsic functional host membranes capable of docking guest ligands via facile host-guest interactions. β-Cyclodextrin (β-CD) conjugated to the microcapsule membrane building block serves as the host entity for guest adamantane-linked functional molecules Cyanine5 (Cy5) and Pam