Transforming the concept of connectivity: unveiling tunneling nanotube biology, and their roles in brain development and neurodegeneration.

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Tác giả: Francesca Palese, Malalaniaina Rakotobe, Chiara Zurzolo

Ngôn ngữ: eng

Ký hiệu phân loại: 949.59012 *Greece

Thông tin xuất bản: United States : Physiological reviews , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 694242

Tunneling nanotubes (TNTs) are thin tubular membrane protrusions that connect distant cells, generating a complex cellular network. Over the past few decades, research on TNTs has provided important insights into their biology, including structural composition, formation mechanisms, modulators, and functionality. It has been discovered that TNTs allow cytoplasmic continuity between connected cells, facilitating fast intercellular communication via both passive or active exchange of materials. These features are pivotal in the nervous system, where rapid processing of inputs is physiologically required. TNTs have been implicated in the progression of neurodegenerative diseases and cancer in various
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