For severe local vasculopathy, covered stents are considered the major medical devices in interventional therapy due to their function to isolate lesions and deliver drugs. However, commercial stent-coverings have unsatisfactory drug-loading capacity and lack bioactivity. Silk fibroin (SF) possesses excellent biocompatibility, biodegradability, and endothelialization ability. In this study, we developed a bioabsorbable SF stent-covering loaded with heparin (Hep) via layer-by-layer self-assembly. Hep was embedded in the stent-covering via interfacial adsorption (Hep-SF) or direct blending with SF (Hep/SF). For interfacial adsorption, the Hep loading capacity increased with adsorption time and Hep concentration, reaching up to 589 μg/cm