The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modifications on Colonic Mucin.

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Tác giả: Joon Soo An, Ashwin N Ananthakrishnan, Elizabeth A Creasey, Mark J Daly, Daniel B Graham, Xiebin Gu, Ranad Humeidi, Noriko Oshiro-Rapley, Stuart L Schreiber, Mohammad R Seyedsayamdost, Ramnik J Xavier

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Journal of the American Chemical Society , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 694347

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Colonic mucus forms a first line of defense against bacterial invasion while providing nutrition to support coinhabiting microbes in the gut. Mucus is composed of polymeric networks of mucin proteins, which are heavily modified post-translationally. The full compendium of enzymes responsible for these modifications and their roles in health and disease remain incompletely understood. Herein, we determine the biochemical function of

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