Metabolic Profiling of Breast Cancer Cell Lines: Unique and Shared Metabolites.

• Tác giả: Pietro Ancona, Carlo M Bergamini, Valeria Bertagnolo, Nicoletta Bianchi, Federica Brugnoli, Elena Ferrari, Mariana Gallo, Thelma A Pertinhez, Alberto Spisni, Anna Terrazzan, Stefano Volinia
• Ngôn ngữ: eng
• Ký hiệu phân loại: 004.65 Communications network architecture
• Thông tin xuất bản: Switzerland : International journal of molecular sciences , 2025
• Bộ sưu tập: NCBI
• ID: 69441

Tóm tắt

Breast Cancer (BrCa) exhibits a high phenotypic heterogeneity, leading to the emergence of aggressive clones and the development of drug resistance. Considering the BrCa heterogeneity and that metabolic reprogramming is a cancer hallmark, we selected seven BrCa cell lines with diverse subtypes to provide their comprehensive metabolome characterization: five lines commonly used (SK-Br-3, T-47D, MCF-7, MDA-MB-436, and MDA-MB-231), and two patient-derived xenografts (Hbcx39 and Hbcx9). We characterized their endometabolomes using