PURPOSE: This observational study aimed to explore the association of various vertical skeletal and dentoalveolar components with the hypodivergence facial growth pattern in a Middle Eastern population. METHODS: A total of 320 lateral cephalometric radiographs of Middle Eastern adults were selected and divided, based on their vertical facial growth pattern, equally into two groups: 1) hypodivergent (GoGn/SN ≤ 28°) and 2) normodivergent (28° <
GoGn/SN <
36°). Each group comprised 160 subjects: 80 females and 80 males. A customized cephalometric analysis was performed using the software Viewbox 4 (version 4.0, Viewbox, dHAL Software, Kifissia, Greece). Landmark references were digitized on the cephalometric radiographs to measure vertical skeletal and dentoalveolar variables in the anterior and posterior maxillary and mandibular regions. Multiple regression analyses were performed with SPSS® statistics software (version 17.0, IBM, Chicago, IL, USA). RESULTS: Hypodivergence was primarily determined by the skeletal vertical components, while dentoalveolar components were less important. The main contributors were posterior facial height (S-Go) with 50.0% for males and 46.6% for females, anterior facial height (N-Me) with 47.0% for males and 45.9% for females, as well as the ramus length (Co-Go), ranging from 29.9 to 32.5% for males and 24.3% for females. There was no significant gender-related dimorphism in the evaluated cephalometric components. CONCLUSION: The main contributing factors to hypodivergence were the skeletal mandibular components. Dentoalveolar heights contributed minimally to hypodivergence.