Caffeine and sclareol take the edge off the sedative effects of linalool, possibly through the GABAA interaction pathway: molecular insights through in vivo and in silico studies.

• Tác giả: Md Sakib Al Hasan, Irfan Aamer Ansari, Siddique Akber Ansari, Md Shimul Bhuia, Jannatul Ferdous, Md Amirul Islam, Muhammad Torequl Islam, Emon Mia, Imam Hossen Rakib, Noshin Tasnim Yana
• Ngôn ngữ: eng
• Ký hiệu phân loại: 895.919 Other Tai literatures
• Thông tin xuất bản: Germany : Naunyn-Schmiedeberg's archives of pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 694580

Tóm tắt

Linalool (LIN) has some important neuropharmacological activities, including anxiolytic and sedative effects. It is also clear that it protects experimental animals from convulsions and Alzheimer's disease. On the other hand, caffeine (CAF) and sclareol (SCL) have neurostimulatory potential. This study evaluates the sedative effect and possible molecular mechanisms of CAF with LIN and/or SCL through in vivo and in silico studies. For this, CAF (10 mg/kg) alone or with LIN (50 mg/kg) and/or SCL (10 mg/kg) was intraperitoneally (i.p.) treated before thirty minutes of thiopental sodium (TS) injection (40 mg/kg, i.p.) to the mice and observed for latency and duration of sleep up to 4 h. To understand the possible action mechanisms of these drugs, we also performed molecular docking and pharmacokinetics profile studies with gamma-aminobutyric acid (GABA