PURPOSE: The study determined whether an exergame training (EXT) resulted in greater improvements in health-related outcomes compared to traditional moderate-intensity continuous training (MICT). METHODS: In total, 47 individuals (age 30±11 years) were randomized into an EXT (n = 24) and an MICT group (n = 23). Throughout the eight-week intervention period, the EXT group attended 20-30 min of EXT three times a week while the MICT group completed 20-45 min of MICT three times a week. Before and after the intervention, BMI, waist-to-height ratio, body fat (BF), resting heart rate (HR), root mean square of successive differences between normal heartbeats (RMSSD), standard deviation of all normal-to-normal intervals (SDNN), average time interval between consecutive R-waves (MeanRR), high-frequency power, low-frequency power, ratio of LF to HF power, enjoyment, systolic (SBP) as well as diastolic blood pressure, and peak oxygen consumption (VO RESULTS: The analyses revealed main effects of time for BF, HR, RMSSD, SDNN, MeanRR, high-frequency power, and SBP (ps<
.05). A main effect of group was found for enjoyment (p<
.05) with higher values in the EXT group. Group-by-time interactions (ps<
.05) were observed for HR, SBP, and VO CONCLUSIONS: The EXT was more effective than the MICT in improving VO TRIAL REGISTRATION NUMBER: NCT05894031.