1,2-Acylphosphinylation of Styrenes to Access β-Aryl-γ-ketophosphine Oxides by Irradiation-Induced Radical Relay.

• Tác giả: Yandong Dou, Shilu Fan, Ming-Chen Fu, Shihao Li, Lishuai Lu, Dengyu Yin, Yanwu Zhu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 621.3825 Electrical, magnetic, optical, communications, computer engineering; electronics, lighting
• Thông tin xuất bản: United States : The Journal of organic chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 694628

Tóm tắt

An acylphosphinylation reaction has been devised for the synthesis of β-aryl-γ-ketophosphine oxides, employing styrenes and acyl azolium salts through an irradiation-induced radical relay mechanism. This method effectively constructs C-C and C-P bonds while demonstrating excellent functional group tolerance. Mechanistic studies revealed that a radical-addition-coupling-elimination cascade process was involved in this reaction.