Automated Insulin Delivery in Elderly with Type 1 Diabetes: A Prespecified Analysis of the Extension Phase.

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Tác giả: Roy W Beck, Suzan Bzdick, Anna Casu, Naomi Chaytor, Donna Desjardins, Robert J Henderson, Kamille Janess, Jorge L Jo Kamimoto, Lauren G Kanapka, Craig Kollman, Yogish C Kudva, Kellee Miller, Vishwanath Pattan, Amy J Peleckis, Richard E Pratley, Michael R Rickels, Shafaq Raza Rizvi, Ruth S Weinstock, Keri J Whitaker

Ngôn ngữ: eng

Ký hiệu phân loại: 297.1248 Sources of Islam

Thông tin xuất bản: United States : Diabetes technology & therapeutics , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 694632

The Automated Insulin Delivery in Elderly with Type 1 Diabetes (AIDE T1D) trial randomized 82 adults ≥65 years with type 1 diabetes (T1D) to hybrid closed loop (HCL), predictive low glucose suspend (PLGS), and sensor-augmented pump (SAP) therapy in a randomized crossover trial. Seventy-five of the 78 completers joined an extension phase in which they were offered the pump mode of their choice for an additional 3 months. Mean age was 71 ± 4 years (range 65-86 years) and mean duration of T1D was 42 ± 17 years (range 1-68 years). Use of HCL was selected by 91%, PLGS by 8%, and continuous glucose monitoring with injections by 1%. For participants selecting HCL, time-in-range 70-180 mg/dL was similar in the randomized controlled trial and extension phase (mean 75% ± 10%). One severe hypoglycemic event was reported. HCL was preferred over PLGS or SAP and remained effective in older adults with T1D. Clinical Trial Registration: NCT04016662.
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