Plate fixation is the primary treatment for clavicle fractures, but standard plates often fail, requiring reoperation due to irritation, bending, or fracture. These issues are linked to poor geometric fit suboptimal plate thickness, and material performance. This study proposes a personalized clavicle plate design methodology for middle one-third fractures. Using a reverse engineering approach, a 3D model of a 15-B1.2 oblique fractured clavicle bone is created from CT scan data. Customized plates of varying thicknesses are designed and simulated using titanium, stainless steel, and cobalt-chromium-molybdenum alloys. This research proposes a methodology based on finite element modeling (FEM) to assess structural stability, safety, and fatigue life by analyzing stresses and displacements under diverse loading conditions. This investigation aims to improve clinical decisions and patient outcomes through personalized treatments and enhanced fracture stability.