Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model.

• Tác giả: Richard Efem, Han V Han, Ya-Ping Jiang, Richard Z Lin, Kevin Lu, Sara Maimouni, Valeria Montoya, Barbara Rosati, Ando Van Der Velden, Wei-Xing Zong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: England : eLife , 2025
• Bộ sưu tập: NCBI
• ID: 694842

Tóm tắt

Most human pancreatic ductal adenocarcinoma (PDAC) are not infiltrated with cytotoxic T cells and are highly resistant to immunotherapy. Over 90% of PDAC have oncogenic KRAS mutations, and phosphoinositide 3-kinases (PI3Ks) are direct effectors of KRAS. Our previous study demonstrated that ablation of