One-Pot Decarbonylative Borylation of Aliphatic Aldehydes.

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Tác giả: Chang Lian, Fanyang Mo, Jianning Zhang, Lei Zhang

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : The Journal of organic chemistry , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 694887

We present a mild and direct method for the radical borylation of simple aliphatic aldehydes. By employing an enamine and a photocatalyst under light irradiation, aldehydes can be transformed effectively into alkyl boronic esters via a formal decarbonylative process. This alternative route for radical borylation synthesis can not only be applied to the transformation of primary, secondary, and tertiary aldehydes but also be adapted to other radical conversion reactions through the generated alkyl radical intermediate. Mechanistic studies indicate that 4-alkyl-1,4-dihydropyridines, formed in situ from the aldehyde and enamine, are the key intermediate for the borylation process.
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