This study aimed to examine the mediating roles of resilience and meaning-centered coping in the relationships between life satisfaction and posttraumatic growth and depreciation. The sample consisted of 255 participants (70% females, Mage = 23.35), who directly experienced the earthquakes that occurred in Turkey on February 6, 2023. Using an online survey, participants answered self-reported questions about their perceived life satisfaction, posttraumatic growth, depreciation, resilience, and meaning-centered coping. Findings showed that life satisfaction significantly predicted resilience, meaning-centered coping, and posttraumatic depreciation. Resilience and meaning-centered coping significantly predicted both posttraumatic growth and depreciation. Importantly, resilience and meaning-centered coping significantly mediated the association of life satisfaction with posttraumatic growth and depreciation. In conclusion, the findings of this study have important implications for customizing interventions designed to enhance the resilience and coping mechanisms of individuals dealing with traumas, including those with posttraumatic stress disorder.