p53 activates circASCC3 to repress R-loops and enhance resistance to chemotherapy.

• Tác giả: Mingming Cao, Bing Chen, Yajie Chen, Jun Deng, Yu Gan, Qian Hao, Xianghuo He, Ruixuan Huang, Shenglin Huang, Yingdan Huang, Jing Tong, Bangxiang Xie, Chen Xiong, Xiang Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 636.7538 Dogs
• Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025
• Bộ sưu tập: NCBI
• ID: 695099

Tóm tắt

The tumor suppressor p53 can trigger tumor resistance to chemotherapy by facilitating DNA damage repair and maintaining genomic integrity. Here, we report that a p53-induced circular RNA circASCC3 promotes chemotherapeutic resistance by resolving R-loops. Our results reveal that p53 directly activates the transcription of