Cryo-ET reveals the in situ architecture of the polar tube invasion apparatus from microsporidian parasites.

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Tác giả: Gira Bhabha, Daija Bobe, Nicolas Coudray, Damian C Ekiert, Janet H Iwasa, Mykhailo Kopylov, Rishwanth Raghu, Harshita Ramchandani, Margot Riggi, Mahrukh Usmani, Ellen D Zhong

Ngôn ngữ: eng

Ký hiệu phân loại: 133.594 Types or schools of astrology originating in or associated with a

Thông tin xuất bản: United States : Proceedings of the National Academy of Sciences of the United States of America , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 695108

Microsporidia are divergent fungal pathogens that employ a unique harpoon-like apparatus called the polar tube (PT) to invade host cells. The long PT is fired out of the microsporidian spore over the course of just a few hundred milliseconds. Once fired, the PT is thought to pierce the plasma membrane of a target cell and act as a conduit for the transfer of the parasite into the host cell, which initiates infection. The PT architecture and its association with neighboring organelles within the parasite cell remain poorly understood. Here, we use cryoelectron tomography to investigate the structural cell biology of the PT in dormant spores from the human-infecting microsporidian species,
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