Compared with acidic environments, promoting the water dissociation process is crucial for speeding up hydrogen evolution reaction (HER) kinetics in alkaline electrolyte. Although the construction of heterostructured electrocatalysts by hybridizing noble metals with metal (hydr)oxides has been reported as a feasible approach to achieve high performance, the high cost, complicated fabrication process, and unsatisfactory mass activity limit their large-scale applications. Herein, we report a single-phase HER electrocatalyst composed of single-atom ruthenium (Ru) incorporated into a cobalt oxide spine structure (denoted as Ru SA/Co