Lipid Dynamics at Membrane Contact Sites.

• Tác giả: Pietro De Camilli, Thomas J Melia, Karin M Reinisch
• Ngôn ngữ: eng
• Ký hiệu phân loại: 303.482 Contact between cultures
• Thông tin xuất bản: United States : Annual review of biochemistry , 2025
• Bộ sưu tập: NCBI
• ID: 695169

Tóm tắt

In eukaryotes, lipid building blocks for cellular membranes are made largely in the endoplasmic reticulum and then redistributed to other organelles. Lipids are transported between organelles by vesicular trafficking or else by proteins located primarily at sites where different organelles are closely apposed. Here we discuss transport at organelle contact sites mediated by shuttle-like proteins that carry single lipids between membranes to fine-tune their composition and by the more recently discovered bridge-like proteins that tether two organelles and provide a path for bulk lipid movement. Protein-mediated lipid transport is assisted by integral membrane proteins that have roles in (