PURPOSE: To report the clinical and imaging findings of a patient with right eye progressive vision loss, in whom ocular neurocysticercosis was diagnosed. The patient underwent vitreoretinal surgery with previous antihelmintic treatment, resulting in a successful extraction of the subretinal cyst. METHODS: A patient with subretinal neurocysticercosis underwent a combination of ophthalmic examination, fundus photography, ocular ultrasound, brain MRI, and surgery. RESULTS: A 57-year-old female from La Guajira, Colombia presented with a 2-year history of unilateral subretinal neurocysticercosis and an overlying exudative inferior retinal detachment with multiple areas of RPE atrophy. Different methods of surgery were contemplated to achieve a favorable outcome, until deciding on a microincision vitrectomy surgery. CONCLUSION: An "in vivo" minimally invasive pars plana approach should be considered, given it has proven to be successful in removing intraocular cysts with no postoperative inflammatory response, preserving anatomic and functional integrity.