With the rapid development of the new energy industry, the wastewater discharged from battery production industries has increased significantly, in which N-Methylpyrrolidone (NMP) have aroused widespread attention. It is valuable to develop low-cost biological methods for NMP containing wastewater treatment. In this study, an NMP-driven PD system was acclimated in an sequencing batch reactor (SBR) by gradually replacing the sodium acetate with NMP. The nitrate-to-nitrite transformation ratio (NTR) of the acclimated PD sludge was stabilized around 60 % and reached up to 68.1 %.The TOC removal was maintained above 90 %, and the NO