Age-related differences in task-related modulation of cerebellar brain inhibition.

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Tác giả: Koen Cuypers, Robert M Hardwick, Robin E Heemels, Melina Hehl, Marten Nuyts, Stephan P Swinnen, Shanti Van Malderen, Stefanie Verstraelen

Ngôn ngữ: eng

Ký hiệu phân loại: 241.4 Virtues

Thông tin xuất bản: United States : Neurobiology of aging , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 695301

Age-related reductions in cerebellar integrity predict motor impairments in older adults (OA), but the contribution of cerebro-cerebellar interactions to these impairments remains unclear. Understanding these interactions could reveal underlying mechanisms associated with age-related deficits in motor control. To explore this, twenty younger adults (YA) and twenty OA, all right-handed, participated in a dual-site transcranial magnetic stimulation protocol. Cerebellar brain inhibition (CBI) was measured at rest and during the anticipatory period of a bimanual tracking task (BTT). The results revealed that YA outperformed OA on the BTT. Both age groups demonstrated reduced CBI during the anticipatory period of the BTT compared to CBI at rest, with no differences in CBI levels between both groups. Notably, motor performance was influenced by CBI modulation, as learning progressed (early vs. slightly later short-term learning), and this influence differed between age groups. In summary, resting-state CBI and the task-related release of CBI were maintained in OA, challenging previous assumptions of reduced inhibitory function in OA. However, the modulation of CBI appears to influence short-term motor learning differently for both groups, suggesting potential functional reorganization of the cerebellar neural system.
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