This study proposed investigates the role of forced aeration flow and humidification pulses during solid-state fermentation (SSF) of spent coffee grounds (SCG) in optimizing fungal growth, metabolic activity, and bioactive compound release. Five fermentation conditions with aeration flows (0.5-1.5 L/min) and moisturizing pulses (30-90 mL/d) were evaluated. Chlorogenic acid (CGA), caffeic acid (CA), and quinic acid (QA) were quantified via HPLC, while antioxidant activities (AA) were assessed using ORAC, DPPH, and FRAP methods. The highest CGA yield (76.1 ± 5.2 mg/g SCG