Personal care products and pharmaceuticals, namely sodium diclofenac (DCF), octocrylene (OCT), and sodium dodecyl sulfate (SDS), are relevant chemical products classified as contaminants of emerging concern (CECs). They can enter aquatic ecosystems from various anthropogenic sources. This study examined the acute and chronic toxic effects of exposure to these substances, individually and in binary mixtures (OCT + SDS, SDS + DCF, DCF + SDS). Chronic effects were evaluated at environmentally relevant concentrations. To evaluate the mixtures, the Abbott method was used to predict acute toxicity using the inhibition ratio value, while for chronic effects, the concentration addition (CA) and independent action (IA) models were used for predictive assessment. According to EC50