Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy.

• Tác giả: Lin Chen, Can Cui, Haoshu Cui, Zheng Gong, Bryan Jin, Jie Liu, Feifei Luo, Shaocong Mo, Xuanxuan Pan, Yuru Shen, Huan Song, Yujen Tseng, Guohong Wang, Maolin Ye, Jiayue Zheng, Wanwei Zheng, Bin Zhong, Qi Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 629.1344 Aerospace engineering
• Thông tin xuất bản: United States : Cancer cell , 2025
• Bộ sưu tập: NCBI
• ID: 695638

Tóm tắt

STING is an important DNA sensing machinery in initiating immune response, yet therapies targeting STING have shown poor outcomes in clinical trials. Here, we reveal that STING signaling induces PD-L1