In the field of neonatal care, the integrity of an infant's skin is paramount yet often underestimated. This article provides a comprehensive review of neonatal skin, illuminating the critical necessity for tailored care practices. The authors explore the developmental variances, highlighting the premature skin's vulnerability to external insults and its role in physiological processes, such as thermoregulation and barrier function. This review synthesizes current best practices in neonatal skin care, including hygiene, protection, and treatment protocols. Furthermore, it addresses common dermatological conditions in infants, providing insights into their identification, implications, and management strategies.