Dual action of sphingosine 1-phosphate pathway in in vitro models of global cerebral ischemia.

• Tác giả: Paola Bruni, Francesca Cencetti, Daniele Lana, Elisa Landucci, Giada Magni, Costanza Mazzantini, Gloria Mulas, Domenico E Pellegrini-Giampietro, Anna Maria Pugliese, Clara Santalmasi, Martina Venturini
• Ngôn ngữ: eng
• Ký hiệu phân loại: 949.59012 *Greece
• Thông tin xuất bản: United States : Neurobiology of disease , 2025
• Bộ sưu tập: NCBI
• ID: 695877

Tóm tắt

It is well accepted that sphingolipids play an important role in the pathological process of cerebral ischemia. In the present study we have investigated the involvement of sphingosine 1-phosphate (S1P) pathway in two different in vitro models of global ischemia. In organotypic hippocampal slices exposed to oxygen and glucose deprivation (OGD) we evaluated the mRNA expression of S1P metabolic enzymes and receptors (S1P