Light-matter interaction simultaneously alters both the original material and incident light. Light not only reveals material details but also activates coupling mechanisms. The coupling has been demonstrated mechanically, for instance, through the patterning of metallic antennas, resulting in the emergence of plasmonic quasiparticles and enabling wavefront engineering of light via the generalized Snell's law. However, quantum-mechanical light-matter interaction, wherein photons coherently excite distinct quantum pathways, remains poorly understood. Here, we report on quantum interference between light-induced quantum pathways through the orbital quantum levels and spin continuum. The quantum interference immediately breaks the symmetry of the hexagonal antiferromagnetic semiconductor FePS