PGRMC2 is a pressure-volume regulator critical for myocardial responses to stress in mice.

• Tác giả: Miram Albotaif, Farideh Amirrad, Vivian La, Ashraf M Mohieldin, Surya M Nauli, Sharareh Ohadi, James K Pru, Kiumars Shamloo, Sha Webster
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Nature communications , 2025
• Bộ sưu tập: NCBI
• ID: 696045

Tóm tắt

 Progesterone receptors are classified into nuclear and membrane-bound receptor families. Previous unbiased proteomic studies indicate a potential association between cardiac diseases and the progesterone receptor membrane-bound component-2 (PGRMC2)
  however, the role of PGRMC2 in the heart remains unknown. In this study, we use a heart-specific knockout (KO) mouse model (MyH6•Pgrmc2