Application of the defect distribution index to functional lung MRI of pediatric cystic fibrosis lung disease and controls.

• Tác giả: Marion Curdy, Elisabeth Kieninger, Philipp Latzin, Samal Munidasa, Felix Ratjen, Giles Santyr, Carmen Streibel, Jason Woods, Brandon Zanette
• Ngôn ngữ: eng
• Thông tin xuất bản: Netherlands : Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society , 2025
• Bộ sưu tập: NCBI
• ID: 696159

Tóm tắt

INTRODUCTION: Functional magnetic resonance imaging (MRI) of the lung usually assesses lung impairment as ventilation defect percentage (VDP). However, VDP only reflects the overall burden of disease and does not characterize the regional distribution (i.e. pattern) of defects. The defect distribution index (DDI) is a metric which shows quantitatively how clustered versus scattered defects are with a higher DDI indicating more clustered defects. AIM: To assess the applicability and validity of the DDI to METHODS: The DDI algorithm was applied to fractional ventilation maps previously acquired with RESULTS: The calculation of DDI was feasible for all MRI data. DDI was significantly higher in patients with CF compared to healthy controls (mean difference [95 % CI] CONCLUSION: The DDI is applicable to functional