Attenuating the neuronal response to chronic stress through transcription factor aggregation.

• Tác giả: Florence Besse, Mathilde Solyga
• Ngôn ngữ: eng
• Ký hiệu phân loại: 181.4 *India
• Thông tin xuất bản: England : Trends in neurosciences , 2025
• Bộ sưu tập: NCBI
• ID: 696204

Tóm tắt

How do neurons cope with chronic stress? In a recent study using blind Drosophila models, Shekhar and colleagues uncovered that chronic sensory deprivation induces brain-wide accumulation of aggregates sequestering transcription factors of the Integrated Stress Response (ISR). However, this protective mechanism prevents cells from triggering adapted transcriptional responses upon exogenous stress.