CD44

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Tác giả: Xiang He, Jia Shen, Lunquan Sun, Feiyu Tang, Yuxi Tian, Liang Weng, Bowen Yuan, Yongwei Zhu

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: England : British journal of cancer , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 696473

BACKGROUND: The heterogeneity of tumors significantly impacts on colorectal cancer (CRC) progression. However, the influence of this heterogeneity on the spatial architecture of CRC remains largely unknown. METHODS: Spatial transcriptomic (ST) analysis of AOM/DSS-induced colorectal cancer (CRC), integrated with single-cell RNA sequencing, generated a comprehensive spatial atlas of CRC. Pseudotime trajectory, stemness evaluation, and cell-cell communication analyses explored how CD44 RESULTS: Our findings revealed a distinctive layered ring-like structure within CRC tissues, where CD44 CONCLUSIONS: Our results provide distinctive insights into how tumor heterogeneity reshapes the TME at the leading edge of tumor, thereby promoting CRC progression.
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