A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases.

• Tác giả: Bart De Strooper, Ivana Geric, Anna Martinez-Muriana, Arya Nair, Emanuela Pasciuto, Lutgarde Serneels, Annerieke Sierksma, An Snellinx
• Ngôn ngữ: eng
• Ký hiệu phân loại: 004.338 Systems analysis and design, computer architecture, performance evaluation of real-time computers
• Thông tin xuất bản: England : Molecular neurodegeneration , 2025
• Bộ sưu tập: NCBI
• ID: 696835

Tóm tắt

BACKGROUND: Recent studies highlight the critical role of microglia in neurodegenerative disorders, and emphasize the need for humanized models to accurately study microglial responses. Human-mouse microglia xenotransplantation models are a valuable platform for functional studies and for testing therapeutic approaches, yet currently those models are only available for academic research. This hampers their implementation for the development and testing of medication that targets human microglia. METHODS: We developed the hCSF1 RESULTS: Our results demonstrate the successful transplantation of iPSC-derived human microglia into the brains of hCSF1 CONCLUSION: The hCSF1